General
Preferred name
BI-3802
Synonyms
P&D ID
PD078639
CAS
2166387-65-9
Tags
available
free of charge
molecular glue
PROTAC
probe
Probe info
Probe type
P&D approved
experimental probe
Probe selectivity
protein-selective
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
5
No orthogonal probes found
Similar probes
3
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
COMMENT
Limited oral bioavailability is noted following oral administration in SCID mice. Alternates routes are not explored. Mar 29 2021 - 9:32pm; This is an excellent chemical probe with a novel mechanism of action. May 4 2021 - 1:48pm
DESCRIPTION
BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-¨¤-brac (BTB) domain of BCL6 with an IC50 of ¡Ü3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity[1][2].
DESCRIPTION
BI-3802 is a small molecule that promotes ubiquitin-mediated, proteasomal degradation of the oncogenic transcription factor BCL6 . It binds to BCL6's BTB domain and initiates polymerization of BCL6 into structural foci that become targets for ubiquitination by the SIAH1 E3 ubiquitin ligase. BI-3802's mechanism of action is distinct from those of PROTACs and molecular glue type protein degraders . BI-3802-promoted degradation of BCL6 results in significant derepression of BCL6 target genes and anti-proliferative effects in model cancer cell lines. The chemical structure was claimed in a patent granted to Boehringer Ingelheim in 2018 .
(GtoPdb)
MOA
Molecular Glues
(Chemical Probes.org)
DESCRIPTION
B-cell lymphoma 6 (BCL6) is a known oncogenic driver and frequently overexpressed in many Diffuse large B-cell lymphoma (DLBCL). BI-3802 potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro (IC50 ≤ 3 nM). In a cellular context, BI-3802 inhibits the BCL6::Co-repressor complex formation with an IC50 of 43 nM. Moreover, BI-3802 was found to be a potent and efficacious degrader of the BCL6 protein in many DLBCL cell lines (DC50 = 20 nM in SU-DHL-4 cells).1 The good permeability properties of BI-3802 and the so far unprecedented BCL6 degradation effects make this molecule an ideal in vitro probe compound for testing hypotheses around BCL6 biology. With BI-5273 we also offer a structurally close analog which can be used as a negative control for in vitro experiments (IC50 ~ 10 µM).1
Concept: Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel, Animation: JumpStartVideo.net11
(opnMe Portal)
DESCRIPTION
BI-3802 is a highly potent BCL6 (B-cell lymphoma 6 protein) degrader and inhibits the BTB domain of BCL6 with an IC50 of ≤3 nM.
(Enamine Bioactive Compounds)
DESCRIPTION
BI-3802 is a highly effective oncogenic transcription factor BCL6 degradation agent, inhibits the BTB domain of BCL6, with IC50 ≤ 3 nM. It has anti-tumor activity.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependent on the E3 ligase SIAH1, demonstrating notable antitumor activity[1][2].
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Chemical Probes.org
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
MolGlueDB
Open Science Probes
opnMe Portal
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
9
Molecular Weight
484.2
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
3.33
TPSA
101.38
Fraction CSP3
0.42
Chiral centers
2.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bcl-2 Family
BCL6 degrader
BCL-6
BCL6
Molecular Glues
Orthogonal probe
BI-3812
Pathway
Apoptosis
Solubility
Soluble in DMSO
Control name
BI-5273
Target class
Transcription factor
Target subclass
Transcriptional Repressor
Recommended Cell Concentration
1 uM
Source data
